Table 1 Top ten vertices analyzed using the Double Screening Scheme (DSS) analysis, combining the Density of Maximum Neighborhood Component (DMNC) and Maximum Neighborhood Component (MNC, see the “Methods” section for details; DMNC||MNC65), degree63 or bottleneck 64 approaches, for networks of constructed protein–protein interactions (PPI) from Experiments 1 and 3 (Fig. 6) and Experiment 4 (Fig. 10).
Proteins | DMNC | MNC | Proteins | Degree | Proteins | Bottle-neck | Proteins | Betweenness |
|---|---|---|---|---|---|---|---|---|
1st PPI experiment 1 (TFBSs) and experiment 3 (DE) | ||||||||
IKZF1 | 0.57 | 6 | INPP5D | 8 | INPP5D | 26 | FEZF2 | 791.91 |
CD53 | 0.57 | 6 | ARNT | 8 | HGF | 16 | INPP5D | 756 |
ARHGAP25 | 0.57 | 6 | IKZF1 | 8 | FEZF2 | 15 | PIK3C2B | 746.78 |
INPP5D | 0.65 | 5 | TBC1D10C | 6 | PIK3C2B | 15 | SMARCD2 | 639.68 |
TBC1D10C | 0.65 | 5 | CD53 | 6 | SMARCD2 | 15 | ARNT | 626.43 |
MPEG1 | 0.65 | 5 | ARHGAP25 | 6 | IKZF1 | 10 | IKZF1 | 519.36 |
FLI1 | 0.46 | 3 | FEZF2 | 5 | MYH6 | 10 | LDLR | 479.63 |
NEUROD6 | 0.31 | 3 | PIK3C2B | 5 | ERG | 10 | HGF | 455.06 |
STMN2 | 0.31 | 3 | LDLR | 5 | ARNT | 9 | USH2A | 436.33 |
FEZF2 | 0.31 | 2 | NEUROD6 | 5 | USH2A | 8 | NEUROD6 | 399 |
2nd PPI experiment 4 | ||||||||
WNT8B | 0.67 | 8 | SRC | 15 | PRKACA | 31 | PRKACA | 907.62 |
WNT3A | 0.67 | 8 | CTNNB1 | 12 | SRC | 11 | CTNNB1 | 544.30 |
WNT2 | 0.67 | 8 | PRKACA | 11 | CTNNB1 | 10 | CACNA1C | 456 |
WNT7A | 0.77 | 7 | CBL | 9 | CACNA1C | 7 | OXTR | 390 |
WNT7B | 0.77 | 7 | WNT8B | 8 | OXTR | 6 | SRC | 353.57 |
WNT10A | 0.77 | 7 | WNT5A | 8 | GRIA1 | 6 | CBL | 323.20 |
SFRP5 | 0.77 | 7 | WNT3A | 8 | WNT8B | 5 | GRIA1 | 269.11 |
WNT5A | 0.77 | 7 | WNT2 | 8 | CBL | 5 | COL7A1 | 168 |
MAPK11 | 0.41 | 7 | MAPK14 | 8 | GAB1 | 4 | DLG1 | 161.54 |
TRHR | 0.64 | 5 | MAPK1 | 8 | RARA | 3 | WNT5A | 106.75 |
