Figure 1 | Scientific Reports

Figure 1

From: Trametinib improves Treg selectivity of anti-CCR4 antibody by regulating CCR4 expression in CTLs in oral squamous cell carcinoma

Figure 1

CCR4 expression in CTLs was induced by TCR and cytokine signaling. CMV-CTLs derived from PBMC of HD1 were stimulated with HSC-3pp65 cells or stimulated by immobilized anti-CD3 mAb. On day 2, flow cytometry was performed. CCR4 expression in CMV-CTLs without cytokines (a) and with (b) are shown. The receptors required for CCR4 expression obtained from the results in (a,b), their signaling pathways, the inhibitors used for the experiments in this study, and the sites of action are shown below (c). CCR4 CC chemokine receptor type 4, TCR T-cell receptor, CMV Cytomegalovirus, CTL cytotoxic T-lymphocyte, PBMC peripheral blood mononuclear cells, HD healthy donor, stim. stimulated, non-stim. non-stimulated, IL interleukin, IFN-γ interferon gamma, TNF-α tumor necrosis factor-alpha.

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