Table 4 Multivariate logistic regression at 6-month follow-up.

From: Cardiopulmonary work up of patients with and without fatigue 6 months after COVID-19

 

OR [95% CI]

p value

Model 1

Age, years

0.943 [0.84–1.03]

0.23

Female sex

8.325 [1.21–100.10]

< 0.05

Respiratory disease

3.49 [0.48–33.39]

0.23

Chronic kidney disease

0.03 [0.00–0.93]

0.09

Heart disease

22.58 [0.92–1431.38]

0.08

Diabetes mellitus

2.42 [0.23–27.40]

0.45

Overweight (BMI ≥ 25 kg/m2, < 30 kg/m2)

0.31 [0.02–2.83]

0.32

Obesity (BMI ≥ 30 kg/m2)

2.20 [0.20–35.70]

0.53

Malignancy

4.44 [0.14–214.49]

0.40

Chronic hepatitis

3.42 [0.06–230.88]

0.54

FEV1 [%]

0.93 [0.85–1.00]

0.06

VC [%]

1.08 [0.98–1.19]

0.12

GLS [%]

0.68 [0.42–0.98]

0.07

Model 2

Age, years

0.96 [0.90–1.01]

0.16

Female sex

4.97 [0.98–31.98]

0.06

Heart disease

3.73 [0.49–31.15]

0.20

Diabetes mellitus

0.28 [0.03–1.68]

0.19

Overweight (BMI ≥ 25 kg/m2, < 30 kg/m2)

0.50 [0.07–3.33]

0.48

Obesity (BMI ≥ 30 kg/m2)

1.31 [0.22–8.43]

0.77

Admission to ICU

0.58 [0.07–3.69]

0.58

CRP on hospital admission, [mg/l]

1.00 [0.98–1.01]

0.36

GLS [%]

0.79 [0.59–1.02]

0.09

Model 3

Respiratory disease

0.38 [0.00–7.42]

0.58

Admission to ICU

1.17 [0.05–21.01]

0.91

CRP on hospital admission, [mg/l]

1.00 [0.99–1.02]

0.69

FEV1 [%]

0.97 [0.89–1.05]

0.39

VC [%]

1.03 [0.94–1.15]

0.50

DLCO/VA [%]

0.95 [0.85–1.04]

0.32

Distance in 6MWT, [meters]

1.00 [0.99–1.01]

0.85

  1. Results from three multivariate logistic regressions, response variable is patient-reported fatigue at 6 months follow-up in each model. Regarding model 3: Pulmonary function tests in these models represent percentage of normal values (adjusted for age, gender, height and race). For numerical variables a one unit of change is associated with a change in likelihood of reporting fatigue at 6 months follow-up by the value reported in the OR column. OR > 1 increase the likelihood, while OR < 1 reduce the likelihood.
  2. OR, Odds-Ratio; 95% CI, 95% confidence interval; BMI, Body mass index in kg/m2; FEV1, forced expiratory volume in 1s; VC, vital capacity; GLS, global longitudinal strain; CRP, C-reactive protein; DLco, diffusing capacity for carbon monoxide; VA, alveolar volume.
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