Table 1 Results of the analysis of the nine candidate SNPs selected after the discovery phase of the study.

From: Common variability in oestrogen-related genes and pancreatic ductal adenocarcinoma risk in women

Chr

Gene

SNP

Position

Alleles (M/m)a

MAF (cases/controls)

Phase

OR (95% CI)

P-value

1

NR5A2

rs2816945

199,992,365

C/G

0.257/0.228

PanScan + PanC4

1.17 (1.08–1.26)

8.39 × 10−5

0.218/0.219

PANDoRA

1.16 (0.98–1.38)

0.091

0.248/0.225

Meta-analysis

1.15 (1.07–1.23)

9.57 × 10−5

1

NRAS

rs8453*

115,259,599

G/T

0.156/0.141

PanScan + PanC4

1.15 (1.05–1.27)

2.64 × 10−3

0.138/0.144

PANDoRA

0.98 (0.81–1.19)

0.86

0.151/0.143

Meta-analysis

1.12 (0.89–1.42)

0.332

2

ERBB4

rs11904566

212,354,011

A/G

0.028/0.020

PanScan + PanC4

1.41 (1.13–1.76)

2.53 × 10−3

0.036/0.033

PANDoRA

1.03 (0.78–1.38)

0.788

0.030/0.027

Meta-analysis

1.25 (1.05–1.49)

1.16 × 10−2

3

PIK3CA

rs61796467*

178,900,596

G/A

0.074/0.059

PanScan + PanC4

1.26 (1.10–1.44)

1.03 × 10−3

0.083/0.077

PANDoRA

0.98 (0.81–1.19)

0.86

0.076/0.069

Meta-analysis

1.12 (0.89–1.42)

0.332

4

HSD17B11

rs116113712*

88,295,123

G/A

0.017/0.011

PanScan + PanC4

1.60 (1.17–2.10)

1.43 × 10−3

0.005/0.010

PANDoRA

0.78 (0.40–1.49)

0.45

0.014/0.010

Meta-analysis

1.20 (0.62–2.32)

0.596

7

EGFR

rs138154852

55,125,950

G/A

0.054/0.068

PanScan + PanC4

0.78 (0.68–0.90)

4.98 × 10−4

0.070/0.076

PANDoRA

0.90 (0.70–1.15)

0.381

0.057/0.071

Meta-analysis

0.81 (0.71–0.91)

5.93 × 10−4

8

NCOA2

rs113654977

71,164,275

T/C

0.031/0.040

PanScan + PanC4

0.72 (0.60–0.87)

4.62 × 10−4

0.043/0.037

PANDoRA

1.17 (0.95–1.51)

0.255

0.034/0.039

Meta-analysis

0.94 (0.58–1.45)

0.697

12

PTGES3

rs2950390*

57,055,291

C/T

0.326/0.346

PanScan + PanC4

0.91 (0.85–0.97)

6.28 × 10−3

0.337/0.339

PANDoRA

1.05 (0.94–1.17)

0.379

0.329/0.342

Meta-analysis

0.91 (0.85–1.11)

0.656

17

POLR2A

rs8753

7,417,640

C/T

0.015/0.022

PanScan + PanC4

0.66 (0.51–0.85)

1.20 × 10−3

0.016/0.022

PANDoRA

0.75 (0.51–1.10)

0.140

0.015/0.022

Meta-analysis

0.69 (0.55–0.85)

5.25 × 10−3

  1. All analyses of PanScan and PanC4 data were adjusted by age, and the first 8 principal components. Analysis of PANDoRA data were adjusted for age and country of origin. The meta-analysis was performed applying the fixed-effects model, or random-effects model for SNPs showing heterogeneity. Statistically significant results (P < 0.05) are in bold.
  2. aM stands for major allele, m stands for minor allele.
  3. *Shows SNPs with heterogeneity.
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