Table 2 Significant results of the gene-based analysis.

From: Common variability in oestrogen-related genes and pancreatic ductal adenocarcinoma risk in women

Gene

Chr

N° SNPs

PMulti

PSNPWiseMean

PSNPWiseTop1

Pathways

NR5A2

1

502

4.08 × 10−5

2.51 × 10−3

2.19 × 10−5

ESR-mediated signalling

MED1

17

90

3.14 × 10−3

2.62 × 10−3

3.45 × 10−2

ESR-mediated signalling

NCOA2

8

439

6.38 × 10−3

2.73 × 10−2

9.71 × 10−3

ESR-mediated signalling

RUNX1

21

574

9.01 × 10−3

2.40 × 10−2

2.14 × 10−2

ESR-mediated signalling

  1. The three models used are: (1) SNP-wise Mean, (2) SNP-wise Top 1 and (3) Multi model. The two SNP-wise models examine the individual SNPs present in the gene and subsequently combine the resulting P-values of the SNPs into a gene test statistic, while the multi model runs the basic models (SNP-wise) and combines the resulting P-values into an aggregated P-value for the gene. NR5A2 is significant after the Bonferroni correction (P < 0.05/208 = 2.40 × 10−4).
  2. aThe pathways was identified using the reactome website.
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