Figure 6
Treatment with paeoniflorin-pretreated OLP-MSCs and paeoniflorin-pretreated OLP-MSCs ameliorated experimental skin graft rejection in mice. Paeoniflorin-pretreated MSCs prolonged skin graft survival and reduced the inflammatory response. MSCs (2 × 106) were injected into the recipients. (a) Skin graft changes and histological HE staining, (b) body weight changes, (c) graft rejection scores, (d) a Kaplan–Meier curve of survival time and (e) histological scores showed that OLP-MSCs prolonged the survival time of the skin graft and inhibited the infiltration of lymphocytes. Paeoniflorin-pretreated OLP-MSCs showed improved immunomodulatory function in animals that received skin grafts (**P < 0.01; #P < 0.05). PF, paeoniflorin.
