Figure 6 | Scientific Reports

Figure 6

From: Immune mobilising T cell receptors redirect polyclonal CD8+ T cells in chronic HIV infection to form immunological synapses

Figure 6

Elimination of resting infected CD4+ T cells by PLWH CD8+ T cells. Resting infected HD CD4+ T cells were co-cultured with CD8+ T cells from eight PLWH (E:T of 1:1 or 2:1) with and without m121 ImmTAV (0.5 nM) for 48 h. (a) Percent elimination was normalised to the percentage of Gag+ cells in infected CD4+ T cell cultures alone. For technical reasons, the no ImmTAV condition at an E:T ratio of 2:1 was not included. (b) The percent elimination data from (a) for six of the PLWH with phenotyping data was plotted against CD39 expression in the TEM population with and without m121 ImmTAV. Mean values are indicated by horizontal bars. Groups were analysed by one-way ANOVA with Tukey’s multiple comparisons test or Spearman’s correlation.

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