Table 3 Univariable and multivariable analysis of baseline characteristics associated with overall survival.

From: Imaging and histological features of tumor biopsy sample predict aggressive intrasegmental recurrence of hepatocellular carcinoma after radiofrequency ablation

  

Univariable analysis

Multivariable analysis

 

n

HR

95% CI

P value

HR

95% CI

P value

Age > 65 years old

212

1.04

[0.83;2.39]

0.2

   

Male

212

0.9

[0.51;1.83]

0.9

   

Histological cirrhosis

212

2.92

[1.06;8.07]

0.03

3.35

[1.15;9.37]

0.02

Etiology of liver disease

212

Ref

     

Hepatitis B

 

1.13

[0.4;3.2]

0.8

   

Hepatitis C

 

0.74

[0.29;1.86]

0.5

   

Alcohol

 

1.19

[0.49;2.88]

0.7

   

Other

 

0.33

[0.04;2.79]

0.31

   

AFP level (ng/mL)

205

1

[0.99;1.00]

0.5

   

Child–Pugh class B

208

2.71

[1.23;5.99]

0.01

2.54

[1.06;6.04]

0.03

Solitary nodule

212

0.58

[0.33;1.03]

0.06

   

Tumor size (cm)

212

0.99

[098;1.01]

0.97

   

BCLC stage B

212

2.95

[1.3;6.54]

0.007

2.6

[1.09;6.16]

0.03

Atypical pattern of tumor enhancement

212

1.04

[0.47;2.30]

0.91

   

Non-smooth tumor margin

212

1.77

[1.02;3.07]

0.04

1.58

[0.86;2.88]

0.13

Tumor capsule

212

0.7

[0.43;1.19]

0.2

   

Abnormal vascular peritumoral enhancement

212

0.49

[0.18;1.3]

0.17

   

Irregular circumferential enhancement

 

0.25

[0.03;1.8]

0.17

   

Peri-vascular location

212

0.98

[0.58;1.6]

0.95

   

MTM subtype

212

2.07

[1.05;4.1]

0.03

2.12

[1.04;4.32]

0.03

Edmondson grade 1 or 2

 

0.83

[0.48;1.44]

0.5

   

Biliary marker expression

201

1.78

[0.84;3.76]

0.13

   
  1. AFP, alphafoetoprotein level; BCLC, Barcelona Clinic Liver Classification; HR, hazard ratio; MTM, macrotrabecular massive.
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