Table 5 Univariable and multivariable analysis of characteristics associated with overall survival in patient with non-infiltrative HCC smaller than 3 cm.

From: Imaging and histological features of tumor biopsy sample predict aggressive intrasegmental recurrence of hepatocellular carcinoma after radiofrequency ablation

  

Univariable analysis

Multivariable analysis

 

n

HR

95% CI

P value

HR

95% CI

P value

Age > 65 years old

142

1.57

[0.83;2.96]

0.165

   

Male

142

0.96

[0.44;2.07]

0.909

   

Histological cirrhosis

142

2.75

[0.66–11.45]

0.164

   

Etiology of liver disease

142

      

NASH

16

ref

     

Hepatitis B

14

1.27

[0.34;4.74]

0.724

   

Hepatitis C

58

1.21

[0.40;3.70]

0.735

   

Alcohol

49

2.06

[0.70;6.09]

0.191

   

Other

5

0.00

NA

0.996

   

AFP level (ng/mL)

142

1

[1.00;1.00]

0.445

   

Child–Pugh class B

131

3.65

[1.28;10.36]

0.015

4.42

[1.53;12.78]

0.006

Solitary nodule

142

0.80

[0.39;1.62]

0.530

   

Tumor size (cm)

142

1.01

[0.95;1.06]

0.849

   

BCLC stage A

142

1.09

[0.52;2.28]

0.821

   

Atypical pattern of tumor enhancement

142

0.56

[0.13;2.32]

0.423

   

Non-smooth tumor margin

142

1.46

[0.70;3.07]

0.313

   

Tumor capsule

142

0.59

[0.32;1.11]

0.103

   

Abnormal vascular peritumoral enhancement

142

0.42

[0.10;1.74]

0.231

   

Irregular circumferential enhancement

142

0.59

[0.32;1.11]

0.103

   

Peri-vascular location

142

1.01

[0.52;1.96]

0.970

   

MTM subtype

142

3.19

[1.46;6.95]

0.004

3.60

[1.63;7.97]

0.002

Edmondson grade 1 or 2

142

0.77

[0.40;1.49]

0.441

   

Biliary marker expression

139

1.61

[0.57;4.54]

0.365

   
  1. NASH, non-alcoholic steatohepatitis; AFP, alphafoetoprotein level; BCLC, Barcelona Clinic Liver Classification; HR, hazard ratio; MTM, macrotrabecular massive.
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