Figure 3 | Scientific Reports

Figure 3

From: Analysis of the twenty-six largest outbreaks of tuberculosis in Aragon using whole-genome sequencing for surveillance purposes

Figure 3

Specific SNPs in virulence genes for each WGS-cluster classified by lineage according to the categories of Forrellad et al. and Ramage et al.13,14. The number of categories remains constant among the three main lineages studied (L4.8, L4.3 and L4.1.2.1). The oxidative and nitrossidative stress, other genes related to lipid synthesis, cell wall proteins, synthesis of complex lipids and toxin/antitoxin systems categories are present in the three lineages. For clusters belonging to the L4.4.1.1, L4.9, L4.6.1.1 and L4.1.1.3/X families, there were no common and specific SNPs as only one cluster of each lineage had been sequenced, so comparison was not possible. The categories with more SNPs for these lineages were cell wall proteins, the synthesis of complex lipids and toxin/antitoxin systems. Clusters with more than 90 SNPs were not considered.

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