Table 1 Lineage and number of cases (N) distributed per year of each IS6110-cluster.

From: Analysis of the twenty-six largest outbreaks of tuberculosis in Aragon using whole-genome sequencing for surveillance purposes

Cluster

Lineage

N

2004

2005

2006

2007

2008

2009

2010

2011

2012

2013

2014

2015

2016

2017

2018

2019

2020

SNPs

CLS_2

4.1.2.1

29

3

5

2

7

5

1

1

1

2

0

0

0

2

0

0

0

0

 > 90

CLS_5

4.4.1.1

16

2

2

0

5

0

1

0

1

1

0

0

1

1

0

0

2

0

 ≤ 5

CLS_7*

4.8

178

34

14

18

22

20

9

12

11

5

4

7

8

3

3

5

2

1

 < 12

CLS_8

4.3.4.1

19

6

2

2

3

1

1

1

1

1

1

0

0

0

0

0

0

0

 < 5

CLS_9

4.3.3

15

3

3

1

2

2

0

0

2

0

0

0

0

2

0

0

0

0

14–35

CLS_13

4.8

20

6

6

2

1

0

0

1

0

1

1

0

1

0

1

0

0

0

 ≤ 5

CLS_14

4.1.2.1

42

2

13

2

4

7

3

3

1

2

3

0

0

0

0

0

0

2

 < 12

CLS_15

4.1.2.1

12

2

6

1

1

1

0

0

0

1

0

0

0

0

0

0

0

0

 > 90

CLS_19

4.9

13

1

5

0

1

1

1

1

2

0

0

0

0

0

1

0

0

0

 ≤ 5

CLS_21

4.8

35

0

4

3

8

0

0

6

1

1

5

2

2

1

0

1

0

1

 ≤ 5

CLS_24

4.3.2

39

8

9

1

3

0

4

1

1

3

1

1

1

0

4

1

1

0

 < 12

CLS_26

4.7

19

2

3

1

1

0

1

0

1

1

1

2

1

0

1

3

0

1

 > 90

CLS_28

4.8

13

0

4

1

1

0

1

0

1

1

0

1

1

1

0

1

0

0

 ≤ 5

CLS_30

4.1.2.1

35

2

2

1

1

10

1

3

5

2

2

0

4

0

0

0

2

0

 ≤ 5

CLS_47

4.8

19

2

0

2

1

2

1

1

1

1

0

2

1

1

1

0

3

0

14–35

CLS_49

4.1.2.1

11

0

1

2

1

2

0

1

1

2

0

0

1

0

0

0

0

0

 > 90

CLS_50*

4.1.1.3

21

0

2

6

0

4

2

1

1

0

1

2

0

0

0

2

0

0

 < 12

CLS_67

4.1.2.1

19

0

2

0

3

3

1

1

0

1

2

0

3

1

1

1

0

0

 ≤ 5

CLS_71

4.3.3

19

0

0

1

2

3

2

0

0

0

0

3

0

2

1

0

3

2

 < 12

CLS_91

4.1.2.1

12

0

1

0

0

2

0

3

3

1

0

1

1

0

0

0

0

0

 < 12

CLS_93

4.8

14

0

0

0

0

3

2

1

0

0

2

0

0

1

2

0

3

0

 < 12

CLS_119

4.8

12

0

0

0

0

0

2

0

1

4

1

0

0

2

0

1

1

0

14–35

CLS_152

4.6.1.1

14

0

0

0

0

0

0

2

1

1

0

5

0

0

0

0

2

3

 ≤ 5

CLS_157

4.1.2

10

0

0

0

0

0

0

1

3

1

1

1

1

0

0

0

1

1

14–35

CLS_195

4.3.2

15

0

0

0

0

0

0

0

0

0

6

2

1

5

1

0

0

0

 ≤ 5

CLS_217*

4.3.3

14

0

0

0

0

0

0

0

0

0

0

1

3

6

3

0

1

0

 ≤ 5

  1. The bold indicates the year of the selected isolates of each outbreak for this genomic study.
  2. *Cluster independently studied; therefore, a greater number of cases distributed throughout the duration of the outbreak were sequenced. The column “SNPs” shows the SNP distance between the selected isolates of each cluster.