Figure 1 | Scientific Reports

Figure 1

From: Gradient-based parameter optimization method to determine membrane ionic current composition in human induced pluripotent stem cell-derived cardiomyocytes

Figure 1

Distribution of MSE calculated between the target and simulated APs modified by randomizing the sfx of nine ionic currents in coordinates of MSE-sfx. All MSE data points were plotted on the logarithmic ordinate against the linear sfx. A total of 5,141,382 points were calculated in cell model No. 86 over the range of 1/10 to approximately 10 times the default sfx. Since the configuration of Vm records were largely unrealistic at sfx > 3, MSE points were omitted over sfx > 3.0. To demonstrate the sharp decrease in MSE, the data points were densely populated near the default sfx.

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