Figure 3 | Scientific Reports

Figure 3

From: Gradient-based parameter optimization method to determine membrane ionic current composition in human induced pluripotent stem cell-derived cardiomyocytes

Figure 3

Successful optimization in Cell 86. (A-1) Target AP (Vm,t, red) and AP generated by randomized initial sfxs (Vm,orp, black). (A-2) Vm,t (red) and Vm,orp (black) generated after 50 cycles of adjusting BP. (A-3) Vm: Vm,t (red) and Vm,orp (black) generated by the final sfxs. Im: corresponding time courses of each current for the finalized AP shown in (A-3) Vm. (B-1) Changes in sfxs vs. log(MSE) during a successful optimization process of PS. (B-2) log(MSE) of all BP points during the search process in PS. The initial values of sfxs are plotted by corresponding colors at the top of each sfx-log(MSE) graph.

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