Figure 2 | Scientific Reports

Figure 2

From: Increased CaV1.2 late current by a CACNA1C p.R412M variant causes an atypical Timothy syndrome without syndactyly

Figure 2

(A) Electropherograms of WT and p.R412M. (B) Alignment of p.R412M. (C) Topology of CaV1.2 α-subunit (S, segment; D, domain) with classical TS (TS1, pink circles), TS2 (orange triangles), or atypical TS (yellow diamond) -related mutations. TS1. Timothy syndrome type 1; TS2, Timothy syndrome type 2; Atypical TS, Atypical Timothy syndrome; AID, α1 interacting domain.

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