Figure 3 | Scientific Reports

Figure 3

From: Increased CaV1.2 late current by a CACNA1C p.R412M variant causes an atypical Timothy syndrome without syndactyly

Figure 3

(A) Three sets of representative current traces for WT, R412M, and G406R ICa elicited by the protocol shown in the inset. (B) peak current density–voltage relationships, (C) steady state activation curves and (D) inactivation time constants for three different ICa: WT (black circles, n = 18), R412M (red squares, n = 10) and G406R (blue diamonds, n = 5). *P < 0.05 R412M vs. WT. †P < 0.05 G406R vs. WT. ‡P < 0.05 R412M vs. G406R.

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