Figure 5
(A) Four sets of representative current traces from two different cells expressing either WT (left) or R412M (right) CACNA1C as Ca2+ (black, ICa) or Ba2+ (red, IBa) as a charge carrier at 0 mV (upper panel) and + 20 mV (lower panel). (B) Voltage-dependences were evaluated as r200 (B) and f200 (C) at various depolarization for WT (n = 5) and R412M (n = 5) and are plotted as a function of test membrane potentials. (D) Using the double pulse protocol as shown in Fig. 4A, the voltage-dependency of IBa inactivation was examined for WT (filled black circles, n = 10) and R412M (filled red squares).
