Figure 1

RNA-seq based transcriptome profiling of PBMCs from COVID-19 patients and healthy controls. (a) Volcano plots representing differentially expressed genes (DEGs) with the log2-fold change plotted against the negative log10 p-value for the three groups. Red and blue dots indicate significantly upregulated and downregulated genes, respectively. (b) Venn diagram showing the overlap of DEGs among each comparison. (c) A heatmap shows commonly identified 131 DEGs of HC versus SEVERE and MILD versus SEVERE. Expression levels are normalized to Z-score and cluster by Euclidean distance matrix. (d) Venn diagram showing the overlap of genes among each comparison of two publicly downloaded datasets and our own RNA-seq data. (e) Protein network analysis using the STRING database.