Figure 2
From: Dysregulated thrombospondin 1 and miRNA-29a-3p in severe COVID-19
In severe and fatal COVID-19 patients, IL17RA expression is elevated in monocytes and neutrophils, but THBS1 expression is elevated in platelets. (a) Two-dimensional UMAP projections of single cells from the GSE174072 cohort scRNA-Seq data colored by expression levels of IL17RA and THBS1. (b) Box plots depicting average expression levels of IL17RA and THBS1 in monocyte (top), neutrophil (middle), and platelet (bottom). Patients are grouped by the severity score at the time of sample collection. *P < 0.05; **P < 0.01; ***P < 0.001; n.s not significant at P = 0.05 by two-sided Wilcoxon rank-sum test.
