Table 3 Changes of liver function (the seventh week).

From: Effect of FXR agonist GW4064 in the treatment of hilar cholangiocarcinoma in rats

Related indicators

Control group (n = 20)

Sham operation group (n = 20)

Model group (n = 17)

Treatment group (n = 18)

(ALT)/(U/L)

61.85 ± 2.05$

62.14 ± 2.23$$

158.37 ± 4.87

122.59 ± 3.16$$$

(AST)/(U/L)

63.62 ± 2.14&

64.36 ± 2.38&&

161.67 ± 4.29

128.71 ± 3.09&&&

(TC)/(mmol/L)

2.53 ± 0.12*

2.55 ± 0.14**

6.61 ± 0.17

5.24 ± 0.16

(TBA)/(μmol/L)

1.75 ± 0.08#

1.74 ± 0.07##

5.27 ± 0.13

4.62 ± 0.14

(TBIL)/(μmol/L)

3.07 ± 0.05@

3.21 ± 0.06@@

5.76 ± 0.08

4.23 ± 0.07@@@

(DBIL)/(μmol/L)

1.73 ± 0.07^

1.71 ± 0.05^^

3.92 ± 0.07

2.88 ± 0.13^^^

  1. In control group, $P < 0.05, &P < 0.05, *P < 0.05, #P < 0.05, @P < 0.05, ^P < 0.05 compared with the model group. In sham operation group, $$P < 0.05, &&P < 0.05, **P < 0.05, ##P < 0.05, @@P < 0.05, ^^P < 0.05 compared with the model group. In treatment group, $$$P < 0.05, &&&P < 0.05, @@@P < 0.05, ^^^P < 0.05 compared with the model group. The levels of total cholesterol, total bilirubin, direct bilirubin, alanine aminotransfease and aspartate transaminase, in model group and treatment group were higher compared with the other two groups. However, in the seventh week, after GW4064 treatment, the damaged liver function of rats in the treatment group was gradually recovered.
  2. ALT alanine aminotransfease, AST aspartate transaminase, TC total cholesterol, TBA total bile acids, TBIL Total bilirubin, DBIL direct bilirubin.
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