Figure 4
From: Optogenetic restoration of high sensitivity vision with bReaChES, a red-shifted channelrhodopsin
The pupil light reflex response in animals exposed to different intensities of 590 nm light stimulation 10 months after treatment. (A) Wild-type (WT) and dystrophic (Dys) animals treated with control vector showed constriction at all levels of stimulation, with the largest proportion of animals responded to the highest level of light stimulus following 5 s of light exposure. The percent pupil size over a 5-s period following exposure to different light intensities ranging from 1.49 (B), 15.9 (C), 16.6 (D) log photons cm−2 s−1. (N = 9 bReaChES-injected dys mice, N = 8 control-injected dys mice, N = 5 bReaChES-injected WT mice and N = 8 control-injected WT mice) Error bars indicate ± SD. *p < 0.05, **p < 0.001, ***p < 0.001 one-way ANOVA with one-sided Dunnett’s post hoc test.
