Figure 8
From: Anti-biofilm activity of caffeine against uropathogenic E. coli is mediated by curli biogenesis
Schematic representation of inhibition of E. coli biofilm by Caffeine. Csg D promotes curli biogenesis, leading to the production of curli fibers and the formation of robust biofilms. Csg A and Csg B are major structural units, while Csg E and Csg F are accessory proteins that promote curli subunit transport through Csg G pores. In the periplasm, CsgC prevents CsgA from polymerizing. A sec signal sequence is encoded for translocation into the periplasm by all the proteins encoded by the csg operons, except for CsgD. In the diagram above, red arrows indicated the result of adding caffeine and demonstrated that it decreased the production of curli and E. coli biofilms.
