Figure 7
From: A link between agrin signalling and Cav3.2 at the neuromuscular junction in spinal muscular atrophy
Flunarizine reduces the increased Txnip expression levels in skeletal muscles of SMA model mice. (A) Txnip RNA levels in the soleus, plantaris and tibialis in vehicle- (V) and flunarizine (FZ)-treated controls (Ctrl) and SMA model mice. Vehicle-treated control (Ctrl V) is given an arbitrary value of 1. NS not significant (P > 0.05), *P < 0.05, ** < 0.01, ***P < 0.001, Student’s t test (3 mice per group). (B) Muscle fiber immunostaining with anti-TXNIP (green) and anti-MyHC7 (red) antibodies is shown for the soleus from vehicle- and flunarizine-treated control and SMA mice at P11. (C) Columns represent the percentage of fibers strongly TXNIP-positive (3 mice per group). Error bars represent SD from the mean values. Scale bar, 30 μm.
