Table 7 Pharmacokinetic parameters of SET-M33 on day 1 and day 28 of 4 weeks of daily intravenous (slow bolus) administration to male and female rats at 5, 9 and 15 mg/kg/day (group mean values).
From: Safety evaluations of a synthetic antimicrobial peptide administered intravenously in rats and dogs
Time | Parameters | Units | 5 mg/kg/day | 9 mg/kg/day | 15 mg/kg/day | |||
|---|---|---|---|---|---|---|---|---|
Male | Female | Male | Female | Male | Female | |||
Day 1 | tmax | minutes | 5 | 5 | 5 | 5 | 5 | 5 |
Cmax | ng/mL | 2227 | 2107 | 4563 | 3503 | 6043 | 5727 | |
AUC0-t | ng ∙ h/mL | 692 | 663 | 1433 | 1152 | 2236 | 1944 | |
Day 28 | tmax | minutes | 5 | 5 | 5 | 5 | 5 | 5 |
Cmax | ng/mL | 3017 | 4103 | 5890 | 12,387 | 8170 | 13,567 | |
AUC0-t | ng ∙ h/mL | 938 | 1218 | 1819 | 3558 | 2734 | 4111 | |
