Table 8 Pharmacokinetic parameters of SET-M33 on day 1 and day 28 of 4 weeks of daily intravenous (infusion) administration to male and female beagle dogs at 0.5, 1.5 and 4.0 mg/kg/day (group mean values ± standard deviation of Cmax and AUC0-24).
From: Safety evaluations of a synthetic antimicrobial peptide administered intravenously in rats and dogs
Time | Parameters | Units | 0.5 mg/kg/day | 1.5 mg/kg/day | 4 mg/kg/day | |||
|---|---|---|---|---|---|---|---|---|
Male | Female | Male | Female | Male | Female | |||
Day 1 | tmax | minutes | EOI | EOI | EOI | EOI | EOI | EOI |
tlast | minutes | EOI | 5 | 15 | 15 | 60 | 180 | |
Cmax | ng/mL | 82.4 ± 22.4 | 82.8 ± 19.1 | 274 ± 110 | 345 ± 87 | 816 ± 188 | 1360 ± 220 | |
AUC0-24 | ng ∙ h/mL | 42.2 ± 13.3 | 45.6 ± 10.4 | 157 ± 60 | 196 ± 48 | 569 ± 99 | 991 ± 161 | |
Day 28 | tmax | minutes | EOI | EOI | EOI | EOI | EOI | EOI |
tlast | minutes | 10 | 10 | 60 | 60 | 180 | 360 | |
Cmax | ng/mL | 149 ± 16 | 125 ± 35 | 470 ± 218 | 645 ± 121 | 1490 ± 440 | 1930 ± 350 | |
AUC0-24 | ng ∙ h/mL | 83.0 ± 9.8 | 76.5 ± 25.2 | 416 ± 209 | 402 ± 104 | 1050 ± 150 | 1550 ± 450 | |
