Table 3 Multivariate logistic regression analysis of coagulation/fibrinolysis parameters as independent risk factors for poor prognosis.

From: Hyperfibrinolysis and fibrinolysis shutdown in patients with traumatic brain injury

Factor

Admission

3 h after injury

6 h after injury

12 h after injury

Odds ratio (95% CI)

p

Odds ratio (95% CI)

p

Odds ratio (95% CI)

p

Odds ratio (95% CI)

p

TAT (10 ng/mL increments)

0.93 (0.74–1.17)

0.52

1.01 (0.82–1.26)

0.91

1.00 (0.77–1.31)

0.99

0.96 (0.71–1.30)

0.79

D-dimer (10 μg/mL increments)

1.65 (1.38–1.98)

0.005

1.16 (1.02–1.33)

0.03

1.13 (0.95–1.34)

0.18

1.28 (0.94–1.73)

0.12

PAI-1 (10 ng/mL increments)

1.03 (0.81–1.30)

0.82

1.17 (0.99–1.40)

0.07

1.20 (1.04–1.39)

0.01

1.31 (1.07–1.59)

0.008

Factor

1 day after injury

3 days after injury

7 days after injury

Odds ratio (95% CI)

p

Odds ratio (95% CI)

p

Odds ratio (95% CI)

p

TAT (10 ng/mL increments)

1.11 (0.46–2.66)

0.82

0.81 (0.48–1.37)

0.42

1.49 (0.66–3.12)

0.36

D-dimer (10 μg/mL increments)

1.47 (0.65–3.32)

0.36

15.45 (0.98–243.12)

0.05

1.28 (0.49–3.29)

0.62

PAI-1 (10 ng/mL increments)

1.24 (1.00–1.53)

0.047

0.96 (0.75–1.23)

0.76

1.82 (0.94–3.55)

0.08

  1. Admission: R2 = 0.51; 3 h after injury: R2 = 0.48; 6 h after injury: R2 = 0.45; 12 h after injury: R2 = 0.51; 1 day after injury: R2 = 0.33; 3 days after injury: R2 = 0.25; 7 days after injury: R2 = 0.16.
  2. 95% CI 95% confidence interval, TAT thrombin-antithrombin III complex, PAI-1 plasminogen activator inhibitor-1.
  3. Significant values are in bold.
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