Figure 1

EGFR, MMP9, and MUC4 protein expression in glioma tissue biopsies. Immunohistochemistry was performed on 60 glioma tissue sections with EGFR, MMP9, and MUC4 antibodies. (A) The slides were categorized into three scores according to the percentage of area and intensity of staining. Score 2 represents the highest expression, magnification, 20 ×. (B) Table representing how the scores are distributed according to the percentage of expressing cells and the expression intensity. (C) Stacked bar graphs representing the distribution (contingency) of scores in grade II, grade III, and grade IV glioma for EGFR, MMP9, and MUC4 (N = 60 cases; 20 per grade) . Statistical differences were assessed with the Chi² test (95% confidence interval). For EGFR, there was no statistical significance (ns = non-significant). For MMP9 and MUC4, the higher rate of expression was observed in higher glioma grades (higher levels in GBM compared to III and II). Significance is indicated on the graph as: *Denotes p ≤ 0.05, **p ≤ 0.01, and ***p ≤ 0.001.