Table 2 Top colocalization analysis results for CVD risk factor-associated CpGs.

CpG	Chr	Position	Annotated Gene of CpGs	Relation to CpG island*	Distance to TSS	CVD risk factors associated with CpGs in EWAS catalog	Colocalized traits	Colocalized cis-mQTL variants	PPFC	PPE %
cg14509967	17	48601772	HOXB6	S_shelf	6021	BMI	BMI	rs9299	1	100
cg01856529	12	54259306	CBX5		28,364	HDL	BMI	rs4759073	0.9869	74.42
cg27087650	19	44752538	BCL3	N_shore	4833	BMI	CAD	rs62117206	0.889	46.72
cg05337441	2	21043695	APOB	N_shore	42,266	LDL	CAD	rs668948	0.7996	41.29
cg03676485	7	2524181	LFNG	Island	11,652	HDL	DBP	rs4632959	0.9999	100
cg14099685	11	47524515	CUGBP1		58,578	SBP	DBP	rs34312154	0.993	57.7
cg21506299	6	136784086	MAP3K5		227,040	BMI	HDL	rs6924387	0.9978	99.74
cg27087650	19	44752538	BCL3	N_shore	4833	BMI	HDL	rs1531517	0.9961	59.67
cg27087650	19	44752538	BCL3	N_shore	4833	BMI	LDL	rs4803750	0.9989	100
cg03725309	1	109214962	SARS1	S_shore	1069	BMI:SBP:TG	LDL	rs4970829	0.9962	100
cg03676485	7	2524181	LFNG	Island	11,652	HDL	SBP	rs4632959	0.9999	99.99
cg20278790	20	59008418	CTSZ	S_shore	13,233	WC	SBP	rs151343	0.9979	100
cg11554650	6	30685413	PPP1R18	N_shore	9024	BMI	T2D	rs2516396	0.9835	100
cg00973118	16	324569	AXIN1	N_shore	37,129	BMI	T2D	rs8049265	0.9505	99.33
cg27087650	19	44752538	BCL3	N_shore	4833	BMI	TG	rs4803750	0.9988	98.56
cg14099685	11	47524515	CELF1		58,578	SBP	TG	rs34312154	0.9927	54.52

The top two colocalization results are presented for each outcome trait of interest (BMI, SBP, DBP, HDL, LDL, TG, T2D, & CAD). BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; DBP, high density lipoprotein cholesterol; LDL, low density lipoprotein cholesterol; TG, triglyceride; T2D, type 2 diabetes; CAD, coronary artery disease; PPFC, posterior probability of colocalization; PPE, proportion of PPFC explained by the listed SNP.
*Shore is region from 1 to 2 Kb away from a CpG island and shelf is located at 2–4 Kb from a CpG island. Prefixes N_ and S_ represent north (i.e., upstream) and south (i.e., downstream) regions relative to a CpG island.
TSS, transcription start site.

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