Table 4 Mendelian randomization analysis of putatively causal relations of COVID-19 severity-associated CpGs to COVID-19 severity.

From: Elucidating the genetic architecture of DNA methylation to identify promising molecular mechanisms of disease

CpG

CHR

BP

Gene

Relation to CpG island

Distance to TSS

COVID-19 Host Genetics Initiative GWAS (release 6)

GenOMICC study

N of IVs

Beta

SE

P

N of IVs

Beta

SE

P

cg07796016

1

152779584

LCE1C

 

2275

19

0.08

0.26

0.76

22

− 0.35

0.28

0.20

cg14859874

1

154238265

UBAP2L

 

45,616

36

0.64

0.21

0.002

37

0.65

0.18

0.0002

cg17515347

1

159047163

AIM2

 

22,321

13

1.13

0.46

0.02

13

0.34

0.44

0.44

cg17178900

1

205818956

PM20D1

Island

21,802

31

− 0.54

0.16

0.0007

31

− 0.46

0.17

0.008

cg14893161

1

205819251

PM20D1

S_Shore

22,097

34

− 0.69

0.17

6.1e−05

38

− 0.54

0.17

0.002

cg08309069

6

31240651

HLA-C

S_Shore

4124

46

− 0.40

0.19

0.04

45

0.31

0.28

0.28

cg05030953

6

31241000

HLA-C

S_Shore

4473

50

− 0.24

0.15

0.10

43

0.47

0.18

0.01

cg02872426

6

110736772

DDO

 

27,247

28

0.77

0.27

0.004

27

0.39

0.28

0.16

cg12682382

8

74787918

UBE2W

N_Shelf

95,586

28

0.18

0.17

0.29

27

0.03

0.19

0.88

cg13571460

9

124989337

LHX6

Island

24,475

17

0.10

0.35

0.78

18

− 0.21

0.33

0.53

  1. IVs are independent cis-mQTL variants with linkage disequilibrium R-squared < 0.1. Inverse variance weighted (IVW) method was used to conduct Mendelian randomization analysis, using data from two COVID-19 GWAS (COVID-19 Host Genetics Initiative20 and GenOMICC study19).
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