Table 1 Bacterial burden in thigh tissue.

From: Influence of tramadol on bacterial burden in the standard neutropenic thigh infection model

Thigh

Untreated

Tramadol

Statistical comparison

E. faecalis (ATCC 29212, low inoculum)

6.05 ± 1.3

6.29 ± 1.5

0.7301

E. faecalis (ATCC 29212, high inoculum)

7.17 ± 1.3

7.29 ± 1.3

0.9895

S. aureus (MSSA, ATCC 29213)

8.26 ± 0.2

8.69 ± 0.3

0.1429

S. aureus (MRSA, ATCC 33591)

7.19 ± 0.9

7.77 ± 0.4

0.1429

P. aeruginosa (24 h, ATCC 27853)

5.02 ± 1.5

3.24 ± 0.6

0.1429

P. aeruginosa (48 h, ATCC 27853)

3.39 ± 1.5

3.52 ± 1.1

0.9119

K. pneumoniae (ATCC 43816)

5.31 ± 1.4

7.12 ± 1.5

0.4740

A. baumannii (ATCC 19606)

7.57 ± 0.6

7.60 ± 0.8

0.4740

E. coli (ATCC 25922)

9.25 ± 0.2

9.32 ± 1.2

0.9372

  1. Median bacterial burden as well as standard deviation expressed as log10 cfu/g tissue in thigh for the untreated and the tramadol-treated group for E. faecalis ATCC 29212 (low and high inoculum), S. aureus strains ATCC 29213 and ATCC 33591, P. aeruginosa ATCC 27853 (readout after 24 and 48 h), K. pneumoniae ATCC 43816, A. baumannii ATCC 19606, E. coli ATCC 25922. Statistical testing was performed using a Kolmogorov–Smirnov test.
  2. P values are indicated in the respective column.
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