Table 2 Effect of ΔPes and ΔPL on associations between pendelluft20-25 frequencies and biomarker ratios.

From: Inflammatory biomarkers and pendelluft magnitude in ards patients transitioning from controlled to partial support ventilation

Predictor

Estimate

R2

t-value

p-value

Model 1: IL-8 ratio = β0 + β1*pend20 + β2*ΔPes

pendelluft-20

1.485

0.085

1.398

0.177

ΔPes

0.018

 

0.494

0.626

Model 2: IL-8 ratio = β0 + β1*pend20 + β2*ΔPL

pendelluft-20

1.324

0.075

1.286

0.212

ΔPL

0.002

 

0.056

0.956

Model 3: IL-8 ratio = β0 + β1*pend25 + β2*ΔPes

pendelluft-25

4.631

0.228

2.492

0.021

ΔPes

0.037

 

1.079

0.292

Model 4: IL-8 ratio = β0 + β1*pend25 + β2*ΔPL

pendelluft-25

3.942

0.188

2.200

0.039

ΔPL

− 0.011

 

− 0.266

0.793

Model 5: IL-18 ratio = β0 + β1*pend20 + β2*ΔPes

pendelluft-20

0.553

0.169

1.949

0.065

ΔPes

− 0.001

 

− 0.083

0.934

Model 6: IL-18 ratio = β0 + β1*pend20 + β2*ΔPL

pendelluft-20

0.558

0.169

2.038

0.054

ΔPL

0.001

 

0.086

0.932

Model 7: IL-18 ratio = β0 + β1*pend25 + β2*ΔPes

pendelluft-25

1.577

0.355

3.309

0.003

ΔPes

0.005

 

0.601

0.554

Model 8: IL-18 ratio = β0 + β1*pend25 + β2*ΔPL

pendelluft-25

1.500

0.348

3.327

0.003

ΔPL

− 0.037

 

− 0.370

0.715

Model 9: Caspase-1 ratio = β0 + β1*pend20 + β2*ΔPes

pendelluft-20

1.025

0.235

1.856

0.078

ΔPes

− 0.021

 

− 1.112

0.279

Model 10: Caspase-1 ratio = β0 + β1*pend20 + β2*ΔPL

pendelluft-20

1.141

0.225

2.131

0.045

ΔPL

0.021

 

0.978

0.339

Model 11: Caspase-1 ratio = β0 + β1*pend25 + β2*ΔPes

pendelluft-25

2.611

0.336

2.659

0.001

ΔPes

− 0.012

 

− 0.646

0.525

Model 12: Caspase-18 ratio = β0 + β1*pend25 + β2*ΔPL

pendelluft-25

2.728

0.334

2.952

0.008

ΔPL

0.012

 

0.654

0.520

  1. Pendelluft-20 and pendelluft-25 represent the pendelluft frequency at magnitudes of − 20% and − 25%, respectively. ΔPes: negative deflection of esophageal pressure (Pes) from the onset of inspiratory effort during the ventilatory cycle; ΔPL, tidal change in transpulmonary pressure, calculated as airway pressure (Paw) minus Pes, between the maximum and minimum values of the ventilatory cycle; VT (mL/kg PBW): tidal volume measured in mL/kg of predicted body weight.
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