Table 2 Fisher's exact test results between immunohistochemistry status and response.

From: Tumor-infiltrating immune cell status predicts successful response to immune checkpoint inhibitors in renal cell carcinoma

Molecular biomarker

Responder

Non-responder

p value

CD8

Positive

22

11

0.037

Negative

10

17

 

CD4

Positive

5

14

0.006

Negative

27

14

 

FoxP3

Positive

8

8

0.778

Negative

24

20

 

CD3

Positive

12

12

0.793

Negative

20

16

 

PD-L1

Positive

15

9

0.297

Negative

17

19

 

CD68

Positive

14

3

0.009

Negative

18

25

 

CD163

Positive

13

15

0.437

Negative

19

13

 

CD57

Positive

8

8

0.778

Negative

24

20

 

BCL-2

Positive

19

18

0.793

Negative

13

10

 

XIAP

Positive

15

12

0.799

Negative

17

16

 

CD20

Positive

10

10

0.787

Negative

22

18

 

TLS

Positive

12

9

0.788

Negative

20

19

 
  1. CD cluster of differentiation, FoxP3 forkhead box P3, PD-L1 programmed death-ligand 1, BCL2 B-cell/CLL lymphoma 2, XIAP X linked inhibitor of apoptosis protein, TLS tertiary lymphoid structures.
  2. Responders: patients with CR, PR, or SD ≥ 10 months, non-responders: patients with PD or SD < 10 months.
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