Table 1 Linear mixed effects models to test for the effects of antibiotic use, age, and time points on alpha diversity. (a) The effects of antibiotic use on species richness (Observed), (b) on biodiversity (Shannon index).
From: Moderate and transient impact of antibiotic use on the gut microbiota in a rural Vietnamese cohort
Variable | Value | b (95% CI) | Standard error b | p-value |
|---|---|---|---|---|
a | ||||
Age (in years) | Age (in years) | 0.086 (−0.425, 0.597) | 0.256 | 0.739 |
Timepoint | months | 0.877 (−0.786, 2.539) | 0.845 | 0.3 |
Antibiotics use | 0–2 weeks | −31.344 (−55.372, −7.316) | 12.213 | 0.011 |
2–4 weeks | −1.333 (−34.442, 31.775) | 16.828 | 0.937 | |
blaNDM positive | Yes | 10.233 (−2.744, 23.211) | 6.597 | 0.122 |
blaCTX-M positive | Yes | −4.509 (−10.607, 1.590) | 3.1 | 0.147 |
Timepoint*[Antibiotics use] | Timepoint*[0–2 weeks] | 5.641 (0.184, 11.098) | 2.774 | 0.043 |
Timepoint*[2–4 weeks] | −2.102 (−11.163, 6.958) | 4.605 | 0.648 |
b | ||||
|---|---|---|---|---|
Age (in years) | Age (in years) | 0.003 (−0.004, 0.009) | 0.003 | 0.448 |
Timepoint | Months | 0.029 (0.002, 0.056) | 0.014 | 0.036 |
Antibiotics use | 0–2 weeks | −0.298 (−0.686, 0.090) | 0.197 | 0.132 |
2–4 weeks | 0.160 (−0.374, 0.694) | 0.271 | 0.555 | |
blaNDM positive | Yes | 0.153 (−0.056, 0.362) | 0.106 | 0.15 |
blaCTX-M positive | Yes | −0.043 (−0.142, 0.055) | 0.05 | 0.386 |
Timepoint*[Antibiotics use] | Timepoint*[0–2 weeks] | 0.036 (−0.053, 0.124) | 0.045 | 0.428 |
Timepoint*[2–4 weeks] | −0.081 (−0.228, 0.065) | 0.074 | 0.274 | |
