Figure 1 | Scientific Reports

Figure 1

From: Optimized APPS-tDCS electrode position, size, and distance doubles the on-target stimulation magnitude in 3000 electric field models

Figure 1

E-Field Modeling Pipeline. E-field modeling entails five main steps. First, the researcher acquires structural MRI scans (i.e., T1w and T2w scans). Next, the structural MRI scans are segmented into different components (top to bottom: skin, bone, cerebrospinal fluid, grey matter, and white matter). Third, the tissue segmentations are combined into a 3D volumetric mesh to create an anatomically accurate head model. Fourth, E-field modeling uses experimentally determined tissue conductivity values to simulate how much electric current applied at the scalp reaches the cortex. Displayed is an example in which 7 × 5 cm electrodes were placed over the left primary motor cortex (M1) and right supraorbital (SO) cortex. Lastly, the researcher performs E-field analyses. See Fig. 2 for detailed description of E-field analyses in this study, which included a region of interest (ROI) analysis, 99th percentile threshold analysis, and focality analysis, defined as a measure of volume stimulated at or above the 50th percentile E-field.

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