Figure 5 | Scientific Reports

Figure 5

From: Natural reservoir Rousettus aegyptiacus bat host model of orthonairovirus infection identifies potential zoonotic spillover mechanisms

Figure 5

Histological lesions and localization of Kasokero virus (KASV) nucleoprotein RNA by in situ hybridization in a KASV-inoculated bat (044,997) euthanized at 3 days post inoculation. (a) A peri-venular aggregate of mononuclear inflammatory cells focally disrupts the hepatic parenchyma. Numerous degenerating hepatocytes are present along the periphery and mixed with the inflammatory cells. Hematoxylin and eosin stain, 40 ×, scale bar 20 µM. (b) Extensive positive hybridization signal for the KASV nucleoprotein gene is present in the cytoplasm of hepatocytes surrounding and within a focus of inflammation. Red chromogen with hematoxylin counterstain, 60 ×, scale bar 20 µM.

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