Figure 2 | Scientific Reports

Figure 2

From: Transcriptomic comparison of primary human lung cells with lung tissue samples and the human A549 lung cell line highlights cell type specific responses during infections with influenza A virus

Figure 2

Comparison of virus-induced genes between AM and AEC yielded a strong shared antiviral response and a set of enriched pathways that was driven by AEC-specific genes (A). The top 10 of these pathways as ranked by p value are shown. Exemplary candidates from the GO term “Immune Response” show that the lack of virus induced genes from this pathway in AM is due to a high basal abundance of these genes. Z- scores were calculated on the basis of transcripts per million (TPM) (B). Broad lack of relative gene induction in AM was confirmed when investigating all 79 genes from this pathway that were part of the AECII-exclusive Venn section (C). Statistical significance was assessed by ANOVA with tukey correction for multiple testing. ***p < 0.001. Classifications: BP = biological process, CC = cell compartment, MP = molecular process, KEGG = Kyoto Encyclopedia of Genes and Genomes, REAC = reactome database. Parts of this Figure were made with Biorender.

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