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Figure 1

From: Patient-specific identification of genome-wide DNA-methylation differences between intracranial and extracranial melanoma metastases

Figure 1

Similarity of methylomes of patient-specific melanoma metastases. Hierarchical clustering of genome-wide methylation profiles of 16 intra- and 21 extracranial metastases from 14 patients (Table 1). Patient-specific metastasis samples are co-clustered together in almost all cases independent of the tissue type in which the metastases were located. This patient-specific rather than tissue-specific clustering of melanoma metastases is given by the order of the metastases labels and illustrated by the patient color gradient below the dendrogram. The samples of four patients that did not cluster together are marked by an asterisk ‘*’. Different tissues from which the metastases were taken are encoded in the metastases labels and highlighted by the tissue color code below the dendrogram (grey: brain, green: lymph node, blue: lung, pink: liver, yellow: skin, purple: soft tissue). The red number above each subcluster in the dendrogram represents the approximate unbiased p value (AU value) determined by bootstrapping, where a value of 100 means that the corresponding subcluster was completely stable.

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