Figure 4 | Scientific Reports

Figure 4

From: Patient-specific identification of genome-wide DNA-methylation differences between intracranial and extracranial melanoma metastases

Figure 4

Methylation alterations in the context of clinical information. Visualization of the number of differentially methylated CpGs between intra- and extracranial metastases (x-axis) in the context of different clinical information of each patient (y-axis). Color coding of the plotted symbols defines if the methylation changes include more CpGs with increased methylation (red) or more CpGs with decreased methylation (blue) in intra- compared to extracranial metastases. Shapes of the plotted symbols highlight the treatment status of the individual patients after the occurrence of a metastasis. (A) Number of differentially methylated CpGs in the context of the time between both metastases of a patient. Negative time means that the intracranial metastasis occurred before the extracranial metastasis. (B) Number of differentially methylated CpGs in relation to treatment status of metastases of individual patients. (C) Number of differentially methylated CpGs in relation to survival from intracranial metastasis. Patient P39 was still alive and is marked with an asterisk ’*’.

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