Figure 4 | Scientific Reports

Figure 4

From: Bone marrow-derived vasculogenesis leads to scarless regeneration in deep wounds with periosteal defects

Figure 4

GS allows regeneration of nerves and appendages of the skin. (a) Schematic drawings of the deep wounds with or without GS application is shown at various time points. (b–g) PGP 9.5 (red)-positive cells (arrowheads) are scattered at 2 w pw and commence to form assemblies after 4 w pw in GS (+) rats but not in GS (−) rats. (h–n) Lef1 (red) is positive in the dermal papilla of de novo hair follicles (arrowheads) after 4 w pw in GS (+) rats but not in GS (−) rats. (n) High-power view showing that BMDCs are Lef1-negative. n = 4 for each. The experiments were repeated twice. HF hair follicles, Scale bars, 30 μm.

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