Figure 3 | Scientific Reports

Figure 3

From: Combination of esomeprazole and pirfenidone enhances antifibrotic efficacy in vitro and in a mouse model of TGFβ-induced lung fibrosis

Figure 3

The effect of esomeprazole (Eso), pirfenidone (Pir) or the combination on the contractility of IPF lung fibroblasts using cell contraction assay. The cells were treated with TGFβ (10 ng/mL) for 24 or 48 h in the absence or presence of esomeprazole (100 µM), pirfenidone (1 mM) or esomeprazole (100 µM) and pirfenidone (1 mM) combination. The contractility of cells embedded in collagen gels was followed over time and the area of the gel was calculated for comparison. Data represents three independent experiments. *p < 0.05 vs TGFβ only control and +p < 0.05 vs pirfenidone alone group.

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