Figure 2 | Scientific Reports

Figure 2

From: Intraoperative abobotulinumtoxinA alleviates pain after surgery and improves general wellness in a translational animal model

Figure 2

Effects of aboBoNT-A, saline, and liposomal bupivacaine on the number of animals exhibiting postsurgical pain-related versus normal responses in each group. Mechanical sensitivity/withdrawal force (A), DBS (B) and approaching time (C) in animals that received a full-skin and muscle incision and retraction surgery (Day 0), followed by intraoperative treatment with either aboBoNT-A (100 U, 200 U, or 400 U), saline or liposomal bupivacaine (n = 6/group). Panel (A) shows the number of animals (N) with normal mechanical sensitivity (WF ≥ 26 g) vs hypersensitivity/allodynia (WF < 26 g). Panel (B) shows the number of animals exhibiting moderate to high distress (DBS ≥ 2) vs those with minimal or no distress (DBS < 2). Panel (C) shows the number of animals that initiated approach in ≤ 120 s or those that took more than 120 s in the Approaching test. AboBoNT-A, abobotulinumtoxinA; DBS, distress behavior score; U, unit.

Back to article page