Figure 4 | Scientific Reports

Figure 4

From: Metformin enhances the antitumor activity of oncolytic herpes simplex virus HF10 (canerpaturev) in a pancreatic cell cancer subcutaneous model

Figure 4

Combination therapy efficiently enhances dendritic cell activity. Mice were inoculated with Pan02 tumors as indicated in Fig. 1a, and tumors and TDLNs were collected as previously shown. (a) Bar graphs show the percentage of DCs (MHC-II+ CD11c+) on the injected and contralateral sides. (b) Bar graphs show the percentage of MHC-I expression on DCs on the injected and contralateral sides. (c) A representative dot plot shows cDC1 (CD103+ CD11blow) from cDCs (MHC-II+ CD11c+ CD8α+) on the injected and contralateral sides. (d) Bar graphs show the percentage of cDC1 from cDCs on the injected and contralateral sides. (e) Representative histograms show XCR-1 expression on cDC1 on the injected and contralateral sides. (f) Bar graphs show the percentage of XCR-1 expression on cDC1 on the injected and contralateral sides. (g) A bar graph shows the percentage of cDC1 from DCs in TDLNs. (h) A bar graph shows the percentage of XCR-1 expression on cDC1 in TDLNs. Data are presented as mean ± SD (n = 4 mice). This experiment was conducted at least two times. One-way ANOVA with a post-hoc Tukey’s tests was performed. * p < 0.05, ** p < 0.01, *** p < 0.001.

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