Table 1 Fractional tumor volume (FTV) after treatment with C-REV, either alone or in combination with metformin.

From: Metformin enhances the antitumor activity of oncolytic herpes simplex virus HF10 (canerpaturev) in a pancreatic cell cancer subcutaneous model

Injected side

Contralateral side

 

FTV

FTV

E-FTV

O-FTV

E-FTV/O-FTVa

 

FTV

FTV

E-FTV

O-FTV

E-FTV/O-FTVa

Days

C-REV

Met

Comb

Comb

Comb

Days

C-REV

Met

Comb

Comb

Comb

0

0.97103129

0.88412514

0.85851318

0.86906141

0.9878625

0

1.1159601

1.0286783

1.14796394

1.09600998

1.04740282

3

0.67217525

0.68985396

0.46370276

0.47386626

0.97855197

3

0.78076923

0.91846154

0.71710651

0.54192308

1.32326254

6

0.66928952

0.71765795

0.48032094

0.36241611

1.32533001

6

0.65195566

0.83078854

0.54163729

0.38883079

1.39298971

9

0.6487931

0.77431034

0.50236721

0.35506897

1.41484405

9

0.55093712

0.71659613

0.39479941

0.35

1.12799831

14

0.5735134

0.67730342

0.38844258

0.34741886

1.11808144

14

0.5846316

0.71078833

0.41554932

0.36066534

1.15217427

  1. FTV, fractional tumor volume (mean tumor volume experimental/mean tumor volume control); E- FTV, expected FTV (mean FTV of C-REV) × (mean FTV of metformin); O-FTV, observed FTV.
  2. aSynergic effect: E-FTV/O-TV>1 in bold.
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