Figure 5
From: Global patterns of prognostic biomarkers across disease space
Example of a disease cluster (Cluster 35) formed by UMAP-DBSCAN Algorithm. (A) Heatmap of mean weighted hazard ratios. The cluster consists of seven diseases—N18 Chronic renal failure, M10 Gout, I10 Essential (primary) hypertension, N17 Acute renal failure, I48 Atrial fibrillation and flutter, I50 Heart failure, I51 Complications and Ill-defined descriptions of heart disease. Diseases in this cluster share a common profile of biomarkers associated with reduced risk (Albumin, HDL, Hemoglobin Conc), and increased risk with diabetes (HgA1c) and kidney function (CystatinC, Urea). (B) Correlation of risk profiles for all pairs of diseases in a cluster. The pairwise plots show a strong correlation between hazard ratios.
