Figure 9
Scheme representing the possible effect of the Tenmo-MIP 5 injection on immune system activity, taking into account the JH/ILP feedback loop. Before peptide injection, JH and ILPs suppress the activity of the immune system (A). The injection of Tenmo-MIP 5 causes an inhibition in the production and release of JH from the retrocerebral complex of T. molitor, thereby reducing the effect of this hormone on the level of ILPs. This leads to inhibition of the suppressive role on the immune system, causing its higher activation (B). Cold stress, being a positive regulator of ILPs, causes an increase in the level of ILPs, resulting in partial suppression of immune system activity (C), which may explain the mitigation of the Tenmo-MIP 5 injection by cold stress of almost all tested parameters observed in our study.
