Figure 1
From: Pan-cancer functional analysis of somatic mutations in G protein-coupled receptors
Shannon entropy across GPCR subfamilies versus Shannon global Entropy correlated to cancer-related mutations. A two-entropy analysis plot for all GPCRs with aligned positions. The average entropy across subfamilies (as defined by GPCRdb), i.e. conserved within a subfamily is on the x-axis, and the Shannon entropy on the y-axis. (a) Analysis for all GPCR classes combined. Residues are colored by the frequency of mutations found in the GDC dataset, with blue being low (< 10th percentile), orange medium (10–90th percentiles) and red high (> 90th percentile). Residues with no defined Ballesteros-Weinstein (BW) generic numbers are colored grey. Blue, orange, red, and grey lines represent the mean entropy values for each axis per mutation range (high, medium, low, and non-defined Ballesteros-Weinstein, respectively). Blue, orange, red, and grey shadows represent the standard deviation to the mean entropy values for each axis per mutation range (high, medium, low, and non-defined Ballesteros-Weinstein, respectively). (b) Analysis for Class A GPCRs. (c) Analysis for Class B GPCRs. (d) Analysis for Class C GPCRs. The coloring scheme for panels (b)–(d) is equivalent to that of panel (a).
