Table 2 Investigated motifs, and their residues as noted by their generic residue numbering, both class-specific and Ballesteros-Weinstein.

From: Pan-cancer functional analysis of somatic mutations in G protein-coupled receptors

Motif

Class

Generic residues (Class-specific)

Ballesteros-Weinstein generic residues

DRY

Class A

3.49, 3.50, 3.51a

3 × 49, 3 × 50, 3 × 51

CWxP

Class A

6.47, 6.48, 6.49, 6.50a

6 × 47, 6 × 48, 6 × 49, 6 × 50

nPxxY

Class A

7.49, 7.50, 7.51, 7.52, 7.53a

7 × 49, 7 × 50, 7 × 51, 7 × 52, 7 × 53

HETx

Class B

2.50, 3.50, 6.42, 7.57b

2 × 43, 3 × 46, 6 × 37, 7 × 53

RE

Class B

2.46, 8.49b

2 × 39, 8 × 49

GWGxP

Class B

4.49, 4.50, 4.51, 4.52, 4.53b

4 × 49, 4 × 50, 4 × 51, 4 × 52, 4 × 53

PxxG

Class B

6.47, 6.48, 6.49, 6.50b

6 × 42, 6 × 43, 6 × 44, 6 × 45

R/K

Class F

6.32c

6 × 36

  1. aClass-specific generic residue numbering scheme: Ballesteros-Weinstein8,54.
  2. bClass-specific generic residue numbering scheme: Wootten8.
  3. cClass-specific generic residue numbering scheme: Wang8.