Table 2 Cox regression analyses of predictive factors for variceal bleeding.
Univariate hazard ratio (95% confidence interval) | p values | Multivariate hazard ratio (95% confidence interval) | p values | |
|---|---|---|---|---|
Age | 0.964 (0.928–1.001) | 0.059 | – | |
Male sex | 1.533 (0.644–3.650) | 0.334 | – | |
Liver cirrhosis | 7.246 (1.708–30.742) | 0.007 | – | |
Prior history of acute decompensation | 5.931 (2.602–13.520) | < 0.001 | – | |
Ascites | 2.147 (0.944–4.882) | 0.068 | – | |
Intermediate-advanced HCC | 1.764 (0.716–4.345) | 0.217 | – | |
Portal vein tumor thrombosis | 3.703 (1.078–12.716) | 0.038 | 3.726 (1.045–13.289) | 0.043 |
Potentially curative treatment for HCC | 0.580 (0.251–1.338) | 0.202 | – | |
Prior history of variceal bleeding | 0.000 | 0.988 | – | |
Prior history of treatment for gastroesophageal varices | 0.000 | 0.989 | – | |
Alcohol related hepatitis | 2.336 (0.936–5.834) | 0.069 | – | |
Findings on contrast enhanced CT | ||||
Diameter of intramural vessel in esophagus | 1.543 (1.334–1.784) | < 0.001 | 1.532 (1.316–1.784) | < 0.001 |
Diameter of intramural vessel in fundus | 1.182 (1.068–1.307) | 0.001 | 1.141 (1.030–1.264) | 0.011 |
Diameter of portosystemic shunt | 1.007 (0.920–1.102) | 0.882 | – | |
Laboratory data | ||||
Alanine aminotransferases (U/L) | 1.005 (0.997–1.013) | 0.223 | – | |
Bilirubin (mg/dL) | 1.323 (1.027–1.705) | 0.030 | – | |
Prothrombin time (international normalized ratio) | 2.201 (0.196–24.722) | 0.523 | – | |
Albumin (g/dL) | 0.348 (0.153–0.792) | 0.012 | – | |
Creatinine (mg/dL) | 0.807 (0.370–1.758) | 0.589 | – | |
Platelets (109/L) | 0.943 (0.880–1.011) | 0.943 | – | |
Alfa fetoprotein (ng/ml) | 1.000 (1.000–1.000) | 0.238 | – | |
Albumin-bilirubin (ALBI) score | 3.624 (1.597–8.225) | 0.002 | – | |
Child–Pugh score | 1.723 (1.141–2.601) | 0.010 | – | |
Model for end-stage liver disease (MELD) score | 1.006 (0.872–1.161) | 0.933 | – | |
