Figure 3 | Scientific Reports

Figure 3

From: Biological properties of Staphylococcus virus ΦSA012 for phage therapy

Figure 3

ΦSA012 stability against several environmental conditions. (A) Phage stability against storage conditions at room temperature and 4 °C. ΦSA012 infectivity is indicated as fold changes compared to day 0 and is presented as means ± SD (n = 3). (B) Environmental resistance of ΦSA012 against freeze–thaw cycles. The titer of ΦSA012 is indicated as the fold change compared to cycle 0 and is presented as means ± SD (n = 3). (C) Phage stability at temperatures of 37 °C, 56 °C, and 60 °C. The titer of ΦSA012 is indicated as the fold change compared to 0 h and is presented as means ± SD (n = 3). (D) Phage stability against different pH ranges. The titer of ΦSA012 is indicated as the fold change compared to pH 7 and is presented as means ± SD (n = 3). (E and F) Effects of serum on the plaque-forming activity of ΦSA012. The titer of ΦSA012 is indicated as the fold change compared to 0% FBS and is presented as means ± SD (n = 3). (G) Effects of other phage particles on the plaque-forming activity of ΦSA012. The titer of ΦSA012 is indicated as the fold change compared to non-treated ΦSA012 and is presented as means ± SD (n = 3). The significance compared to the control under each condition was analyzed by Tukey’s test based on one-way ANOVA: *p < 0.05, **p < 0.01.

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