Table 1 EC50s, CC50s and therapeutic indexes of the 5 most potent CADs tested.

From: Desloratadine, an FDA-approved cationic amphiphilic drug, inhibits SARS-CoV-2 infection in cell culture and primary human nasal epithelial cells by blocking viral entry

 

EC50 of SARS-CoV-2 RNA production inhibition (µM)

CC50 in Vero-E6 cells (µM)

Therapeutic index

Loratadine

0.7 ± 0.4

15.5 ± 1.1

23.3

Desloratadine

0.9 ± 0.3

19.9 ± 4.5

22.5

Amitriptyline

8.8 ± 1.4

25.2 ± 1.7

2.9

Imipramine

8.1 ± 0.4

32.8 ± 1.0

4.1

Chlorpromazine

3.6 ± 1.2

8.7 ± 0.2

2.4

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