Figure 5
Generation of follicular helper T (Tfh) cells and germinal center B-cells (GCBs) in the draining lymph node of mice administered S-910823 plus A-910823. (a) Study schedule schematic. Mice were intramuscularly administered 1 μg of S-910823 with or without A-910823 on Day 0 and Day 14. Draining lymph nodes were collected from the immunized animals (n = 5/group) on days 1, 7, 14, 17, and 28 post-first administration. Serum was prepared from the blood samples collected on days 1, 7, 14, 15, 17, and 28 post-first immunization. (b) The number of Tfh cells and a representative contour plot. (c) The number of GCBs and a representative contour plot. (d) Serum levels of CXCL13 in immunized animals. The graph points represent mean cell number values (b, c) or mean concentration values (d). The error bars represent standard error of mean (b, c) or 95% confidence intervals (d).
